Enantioselective Intramolecular C−H Insertion of Donor and Donor/Donor Carbenes by a Nondiazo Approach. Issue 29 (6th June 2016)

• Record Type: Journal Article
• Authors: Zhu, Dong; Ma, Jun; Luo, Kui; Fu, Hongguang; Zhang, Li; Zhu, Shifa
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 29(2016)
• Page Start: 8452
• Page End: 8456
• Publication Date: 2016-06-06
• Subjects: asymmetric catalysis -- carbenes -- heterocycles -- insertion -- rhodium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201604211
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The first enantioselective intramolecular C−H insertion and cyclopropanation reactions of donor‐ and donor/donor‐carbenes by a nondiazo approach are reported. The reactions were conducted in a one‐pot manner without slow addition and provided the desired dihydroindole, dihydrobenzofuran, tetrahydrofuran, and tetrahydropyrrole derivatives with up to 99 % ee and 100 % atom efficiency. Abstract : Generous donor : Enantioselective intramolecular C−H insertion and cyclopropanation reactions of donor and donor/donor carbenes by a nondiazo approach are reported. The reactions were conducted in a one‐pot manner without slow addition and provided the desired dihydroindole, dihydrobenzofuran, tetrahydrofuran, and tetrahydropyrrole derivatives with up to 99 % ee .