Quality of life in idiopathic pulmonary fibrosis: The impact of sleep disordered breathing. (February 2019)

• Record Type: Journal Article
• Authors: Bosi, Marcello; Milioli, Giulia; Parrino, Liborio; Fanfulla, Francesco; Tomassetti, Sara; Melpignano, Andrea; Trippi, Irene; Vaudano, Anna Elisabetta; Ravaglia, Claudia; Mascetti, Susanna; Poletti, Venerino
• Is Part Of: Respiratory medicine. Volume 147(2019)
• Page Start: 51
• Page End: 57
• Publication Date: 2019-02
• Subjects: Idiopathic pulmonary fibrosis -- Quality of sleep -- Quality of life; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2018.12.018
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Purpose: the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF. Methods: we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night polysomnography. The following questionnaires were administered: Epworth Sleepiness Score (ESS), Pittsburg Sleep Quality Index (PSQI), StGeorge's Questionnaire (StGQ). Results: patients were classified in 3 groups:Group A (NO-SDB, 9 patients), Group B(OSAS without sleep–related hypoxemia, 17 patients), Group C(OSAS with sleep–related hypoxemia, 8 patients). Although sleep parameters showed no significant differences among the 3 groups, worse measures were found in group C. 50% of patients (17/34) reported a StGQ score indicating a reduced QoL and the StGQ score was significantly higher in group C patients compared to group A (p < 0.05). In the stepwise multiple regression analysis, 75% of StGQ score variability was significantly predicted by FVC(Forced Vital Capacity) %, DLco (diffusion lung capacity for carbon monoxide)%, PSQI and ESS. Conclusions: in patients with IPF both subjective and polysomnographic poor sleep quality are extremely common features, they are predicted by variables associated with SBD severity and are linked to low QoL. IPF with more severe SDB present poor sleep quality and a worse QoL compared to SDB-free or OSAS-only. Highlights: Poor sleep quality is associated with poor QoL in IPF patients. Poor sleep quality is predicted by variables associated with SDB. IPF patients with more severe SDB have worse QoL compared to SDB-free or OSAS-only.