Physical Activity and Amyloid‐β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment. Issue 8 (22nd July 2015)

• Record Type: Journal Article
• Authors: de Souto Barreto, Philipe; Andrieu, Sandrine; Payoux, Pierre; Demougeot, Laurent; Rolland, Yves; Vellas, Bruno
• Other Names: Gillette‐Guyonnet Sophie investigator.; Carrié Isabelle investigator.; Brigitte Lauréane investigator.; Faisant Catherine investigator.; Lala Françoise investigator.; Delrieu Julien investigator.; Combrouze Emeline investigator.; Badufle Carole investigator.; Zueras Audrey investigator.; Cantet Christelle investigator.; Gardette Virginie investigator.; Morin Christophe investigator.; Kan Gabor Abellan Van investigator.; Dupuy Charlotte investigator.; Caillaud Céline investigator.; Ousset Pierre‐Jean investigator.; Willis Sherry investigator.; Belleville Sylvie investigator.; Gilbert Brigitte investigator.; Fontaine Francine investigator.; Dartigues Jean‐François investigator.; Marcet Isabelle investigator.; Delva Fleur investigator.; Foubert Alexandra investigator.; Cerda Sandrine investigator.; Cuffi Marie‐Noëlle investigator.; Costes Corinne investigator.; Rouaud Olivier investigator.; Manckoundia Patrick investigator.; Quipourt Valérie investigator.; Marilier Sophie investigator.; Franon Evelyne investigator.; Bories Lawrence investigator.; Pader Marie‐Laure investigator.; Basset Marie‐France investigator.; Lapoujade Bruno investigator.; Faure Valérie investigator.; Tong Michael Li Yung investigator.; Malick‐Loiseau Christine investigator.; Cazaban‐Campistron Evelyne investigator.; Desclaux Françoise investigator.; Blatge Colette investigator.; Dantoine Thierry investigator.; Laubarie‐Mouret Cécile investigator.; Saulnier Isabelle investigator.; Clément Jean‐Pierre investigator.; Picat Marie‐Agnès investigator.; Bernard‐Bourzeix Laurence investigator.; Willebois Stéphanie investigator.; Désormais Iléana investigator.; Cardinaud Noëlle investigator.; Bonnefoy Marc investigator.; Livet Pierre investigator.; Rebaudet Pascale investigator.; Gédéon Claire investigator.; Burdet Catherine investigator.; Terracol Flavien investigator.; Pesce Alain investigator.; Roth Stéphanie investigator.; Chaillou Sylvie investigator.; Louchart Sandrine investigator.; Sudres Kristelle investigator.; Lebrun Nicolas investigator.; Barro‐Belaygues Nadège investigator.; Touchon Jacques investigator.; Bennys Karim investigator.; Gabelle Audrey investigator.; Romano Aurélia investigator.; Touati Lynda investigator.; Marelli Cécilia investigator.; Pays Cécile investigator.; Robert Philippe investigator.; Duff Franck Le investigator.; Gervais Claire investigator.; Gonfrier Sébastien investigator.; Gasnier Yves investigator.; Bordes Serge investigator.; Begorre Danièle investigator.; Carpuat Christian investigator.; Khales Khaled investigator.; Lefebvre Jean‐François investigator.; Idrissi Samira Misbah El investigator.; Skolil Pierre investigator.; Salles Jean‐Pierre investigator.; Dufouil Carole investigator.; Lehéricy Stéphane investigator.; Chupin Marie investigator.; Mangin Jean‐François investigator.; Bouhayia Ali investigator.; Allard Michèle investigator.; Ricolfi Frédéric investigator.; Dubois Dominique investigator.; Martel Marie Paule Bonceour investigator.; Cotton François investigator.; Bonafé Alain investigator.; Chanalet Stéphane investigator.; Hugon Françoise investigator.; Bonneville Fabrice investigator.; Cognard Christophe investigator.; Chollet François investigator.; Voisin Thierry investigator.; Peiffer Sophie investigator.; Hitzel Anne investigator.; Zanca Michel investigator.; Monteil Jacques investigator.; Darcourt Jacques investigator.; Molinier Laurent investigator.; Derumeaux Hélène investigator.; Costa Nadège investigator.; Vincent Christian investigator.; Perret Bertrand investigator.; Vinel Claire investigator.; Savy S investigator.; Coley N investigator.;
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 8(2015:Aug.)
• Page Start: 1634
• Page End: 1639
• Publication Date: 2015-07-22
• Subjects: physical activity -- amyloid plaques -- Alzheimer's disease -- older adults -- elderly; Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13530
• Languages: English
• ISSNs: 0002-8614

Abstract

Abstract : Objectives: To examine the associations between amyloid‐ β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose‐response relationship. Design: Cross‐sectional study. Setting: French community‐dwelling people. Participants: Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self‐reported PA and amyloid‐ β brain deposition measured using positron emission tomography (PET) using the PET‐ligand florbetapir F 18 (n = 268). Measurements: A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR−). Results: Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR− participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε 4 carriers or noncarriers. PA was not associated with cognitive function. Conclusion: Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid‐ β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time‐points using objective measures) is involved in the pathophysiology of Alzheimer's disease.