Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase. (7th August 2018)
- Record Type:
- Journal Article
- Title:
- Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase. (7th August 2018)
- Main Title:
- Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase
- Authors:
- Sanzhaeva, Urikhan
Xu, Xuan
Guggilapu, Priyaankadevi
Tseytlin, Mark
Khramtsov, Valery V.
Driesschaert, Benoit - Abstract:
- Abstract: Enzyme activities are well established biomarkers of many pathologies. Imaging enzyme activity directly in vivo may help to gain insight into the pathogenesis of various diseases but remains extremely challenging. In this communication, we report the use of EPR imaging (EPRI) in combination with a specially designed paramagnetic enzymatic substrate to map alkaline phosphatase activity with a high selectivity, thereby demonstrating the potential of EPRI to map enzyme activity.
- Is Part Of:
- Angewandte Chemie. Volume 130:Number 36(2018)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 130:Number 36(2018)
- Issue Display:
- Volume 130, Issue 36 (2018)
- Year:
- 2018
- Volume:
- 130
- Issue:
- 36
- Issue Sort Value:
- 2018-0130-0036-0000
- Page Start:
- 11875
- Page End:
- 11879
- Publication Date:
- 2018-08-07
- Subjects:
- Bildgebung -- Enzyme -- EPR-Spektroskopie -- Nitroxide -- Phosphatasen
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201806851 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 11562.xml