Intratumoral high-payload delivery and acid-responsive release of H2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine. (June 2018)

• Record Type: Journal Article
• Authors: Yang, Tian; Jin, Zhaokui; Wang, Zhihao; Zhao, Penghe; Zhao, Bin; Fan, Mingjian; Chen, Lihua; Wang, Tianfu; Su, Bao-Lian; He, Qianjun
• Is Part Of: Applied materials today. Volume 11(2018)
• Page Start: 136
• Page End: 143
• Publication Date: 2018-06
• Subjects: Hydrogen therapy -- Controlled release -- Drug delivery -- Mesoporous silica nanoparticles -- Anticancer; Materials science -- Periodicals; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1016/j.apmt.2018.01.008
• Languages: English
• ISSNs: 2352-9407

Abstract

Graphical abstract: Highlights: New acid-responsive H2 -releasing nanomedicine of ammonia borane-loaded MSNs. Superhigh H2 loading capacity (130.6 mg/g), far higher than traditional nanomedicine. Sustainable H2 release (>2 days), high cancer therapy efficacy and high bio-safety. Abstract: Hydrogen gas therapy as an emerging and promising therapy strategy has overwhelming advantages especially in bio-safety compared with other gas therapy routes, but is facing a great challenge in the long-term, highly-concentrated, deeply-seated disease site-specific administration of hydrogen gas, owing to its low solubility, high but aimless diffusibility in vivo . Herein, we propose to construct an ammonia borane-loaded mesoporous silica nanomedicine (AB@MSN) to realize the intratumoral high-payload delivery and in situ acid-controlled release of hydrogen gas. The constructed AB@MSN nanomedicine has a superhigh H2 loading capacity (130.6 mg/g, more than 1370 times higher than that of the traditional H2 @liposome nanomedicine) and a highly acid-responsive sustained release behavior, exhibiting high anticancer efficacies and high bio-safety in vitro and in vivo . The proposed nanomedicine-based strategy opens a new window for precision high-efficacy hydrogen therapy.