Botulinum toxin for chronic migraine: Clinical trials and technical aspects. (1st June 2018)

• Record Type: Journal Article
• Authors: Tassorelli, Cristina; Sances, Grazia; Avenali, Micol; De Icco, Roberto; Martinelli, Daniele; Bitetto, Vito; Nappi, Giuseppe; Sandrini, Giorgio
• Is Part Of: Toxicon. Volume 147(2018)
• Page Start: 111
• Page End: 115
• Publication Date: 2018-06-01
• Subjects: Migraine -- Injection paradigm -- Exploratory studies -- Real-life studies -- Technical issues; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2017.08.026
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: OnabotulinumtoxinA has been approved for the prophylaxis of chronic migraine following the demonstration of efficacy in two large controlled trials. Data collected from pragmatic studies in the real-life setting have contributed important additional information useful for the management of this group of extremely disabled and challenging patients. The main findings from these studies are presented and discussed. Highlights: Exploratory trials have documented the efficacy of onabotulinumtoxinA in the prophylaxis of chronic migraine. Real-life studies contributed important information for the long-term management of patients suffering from chronic migraine. Grey areas still exist where recommendations are needed.