Potassium tert-butoxide mediated aerobic hydroxylation of arylboronic acids: an application towards the synthesis of (E)-phenoxy acrylates. (20th June 2019)

• Record Type: Journal Article
• Authors: Muhammad, Ibrahim; Balakrishnan, Madasamy Hari; Sasidharan, Manickam; Mannathan, Subramaniyan
• Is Part Of: New journal of chemistry. Volume 43:Number 28(2019)
• Page Start: 11065
• Page End: 11068
• Publication Date: 2019-06-20
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj02121c
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The first example of potassium tert -butoxide mediated aerobic hydroxylation of arylboronic acids affording phenols is described. Abstract : The first example of potassium tert -butoxide mediated aerobic hydroxylation of arylboronic acids is described. A variety of arylboronic acids bearing both electron donating and withdrawing substituents successfully participated in the reaction and furnished phenols in good yields. This strategy also provides access to one pot synthesis of ( E )-3-phenoxy acrylates from arylboronic acids and propiolates. The solvent plays an important role and a binary solvent system comprising CH3 CN/THF is found to be the best.