Acyl atractyligenin and carboxyatractyligenin glycosides from Antennaria rosea subsp. confinis. (January 2019)

• Record Type: Journal Article
• Authors: Xiao, Yangyang; Lv, Ling; Gou, Ping; Xie, Haihui
• Is Part Of: Phytochemistry. Volume 157(2019)
• Page Start: 151
• Page End: 157
• Publication Date: 2019-01
• Subjects: Antennaria rosea subsp. confinis (Compositae) -- Acyl atractyligenin glycoside -- Acyl carboxyatractyligenin glycoside -- Pancreatic lipase inhibition; GTUSMTDXZXAKTI-PAMNNQAHSA-N; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2018.10.018
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F–M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC50 values ranging from 3.4 to 52.5 μM, suggesting that they participate in the previously observed effect this plant has in reducing triglyceride absorption in rats. Graphical abstract: Eight undescribed acyl ent -kaurene diterpenoid glycosides were identified from the whole herbs of Leontopodium leontopodioides and seven compounds showed potent or moderate pancreatic lipase inhibitory activity.Image 1 Highlights: Eight acyl ent -kaurene diterpenoids were isolated from Leontopodium leontopodioides . Seven compounds exhibited pancreatic lipase inhibitory activity. These compounds did not show α-glucoside inhibitory activity.