ESEM Detection of Foreign Metallic Particles inside Ameloblastomatous Cells. (3rd September 2015)

• Record Type: Journal Article
• Authors: Roncati, Luca; Gatti, Antonietta Morena; Pusiol, Teresa; Barbolini, Giuseppe; Maiorana, Antonio; Montanari, Stefano
• Is Part Of: Ultrastructural pathology. Volume 39:Number 5(2015:Oct.)
• Page Start: 329
• Page End: 335
• Publication Date: 2015-09-03
• Subjects: Ameloblastoma -- cigarette smoke -- dental practice -- environmental scanning electron microscope (ESEM) -- heavy metals -- metallic particles; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.3109/01913123.2015.1042608
• Languages: English
• ISSNs: 0191-3123

Abstract

Abstract: Ameloblastoma is a borderline tumor of odontogenic origin, with a high recurrence rate and possible local aggressiveness. The etiopathogenetic factors involved in its occurrence are not still defined and our study has been precisely aimed to search for novel factors associated with its development. Sections cut from paraffin blocks, containing the representative specimens of 18 different ameloblastomas, collected in a 15-year period (1999–2014), have been observed by an environmental scanning electron microscope, in order to search micro- and nano-sized particles and to identify their composition. In all the neoplastic cases, micro- and nano-sized metallic debris, differing in size and composition, have been detected inside the ameloblastomatous cells. On the contrary, the total absence of metallic particles in the healthy control cases has been emerged. Our results reveal a relationship between ameloblastoma and metallic particulate. The cigarette smoke and the routine dental practice appear the most probable source for the presence of these biopersistant inorganic particles inside the neoplastic cells.