Emerging roles for Interleukin-11 in disease. (4th March 2019)

• Record Type: Journal Article
• Authors: Nguyen, Paul M.; Abdirahman, Suad M.; Putoczki, Tracy L.
• Is Part Of: Growth factors. Volume 37:Number 1/2(2019)
• Page Start: 1
• Page End: 11
• Publication Date: 2019-03-04
• Subjects: Interleukin -- STAT3 -- signaling; Growth factors -- Periodicals; Physiology -- Periodicals; 611
• DOI: 10.1080/08977194.2019.1620227
• Languages: English
• ISSNs: 0897-7194

Abstract

Abstract: Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.