Visual but not verbal working memory interferes with balance in patients after optic neuritis suggestive of multiple sclerosis. (10th August 2019)

• Record Type: Journal Article
• Authors: Brecl Jakob, Gregor; Remšak, Tamara; Olenšek, Jernej; Perellón-Alfonso, Ruben; Šega Jazbec, Saša; Rot, Uroš
• Is Part Of: Neuroscience letters. Volume 707(2019)
• Publication Date: 2019-08-10
• Subjects: Clinically isolated syndrome -- Balance -- Posturography -- Dual-tasking -- Working memory -- Cognitive motor interference; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2019.134288
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Static balance and cognition are impaired in the earliest multiple sclerosis (MS). Cognitive motor interference (CMI) is increased in patients with clinically isolated syndrome. Impaired afferent and efferent information due to demyelination contribute to CMI. Deficits in attention and executive functions lower the threshold for CMI. Abstract: Background: Subtle cognitive deficits are present in almost half of the patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Similarly, subtle balance deficits can be detected at the earliest stages of the disease. To assess cognitive-motor interference (CMI) in nondisabled CIS patients, we studied postural performance using dual task paradigm in CIS patients presenting with optic neuritis. Methods: We prospectively included 20 patients with visual acuity of 0.8 or more within the 3 months from unilateral ON. We also included 20 age, weight, height and education matched healthy subjects. Baseline cognitive performance of the patients was assessed using neuropsychological tests. Balance was studied by posturography (Po) and center of pressure (CoP) measures (maximal medio-lateral, maximal antero-posterior amplitudes, maximal CoP velocity and total CoP path. CMI between static balance and WM was investigated using a dual-task paradigm in three conditions: Po alone, Po+Brooks' visual working memory (WM) task and Po+2-back verbal WM task. Results: The two most commonly affected cognitive domains in the patients were attention (52% of the patients) and executive functions (45% of the patients). Static balance as measured by higher maximal CoP velocity while standing alone (p = 0.02) was impaired in patients. Significantly lower maximal m-l CoP amplitude (p = 0.01) and total CoP path (p = 0.004) in the Po + Brooks' task condition compared to Po alone were observed in the group of ON patients but not in healthy subjects. The cost of dualtasking was highest in the ON patients under Po + Brooks' task (p = 0.04 for the total CoP path parameter). Conclusion: Static balance and cognition are impaired in the earliest MS. CMI between static balance and working memory is higher in the patients and while loading visual working memory. Dual-task paradigms should be used in rehabilitation programmes for patients at the very beginning of the disease.