Collective cell migration: a physics perspective. (28th April 2017)

• Record Type: Journal Article
• Authors: Hakim, Vincent; Silberzan, Pascal
• Is Part Of: Reports on progress in physics. Volume 80:Number 7(2017:Jul.)
• Publication Date: 2017-04-28
• Subjects: collective motion -- wound -- active matter -- out-of-equilibrium -- microfabrication -- cell migration -- cell; Physics -- Periodicals; 530.05
• DOI: 10.1088/1361-6633/aa65ef
• Languages: English
• ISSNs: 0034-4885

Abstract

Abstract: Cells have traditionally been viewed either as independently moving entities or as somewhat static parts of tissues. However, it is now clear that in many cases, multiple cells coordinate their motions and move as collective entities. Well-studied examples comprise development events, as well as physiological and pathological situations. Different ex vivo model systems have also been investigated. Several recent advances have taken place at the interface between biology and physics, and have benefitted from progress in imaging and microscopy, from the use of microfabrication techniques, as well as from the introduction of quantitative tools and models. We review these interesting developments in quantitative cell biology that also provide rich examples of collective out-of-equilibrium motion.