The Effect of an HIV Self-Management Intervention on Neurocognitive Behavioral Processing. (July 2019)

• Record Type: Journal Article
• Authors: Webel, Allison R.; Schreiner, Nathaniel; Salata, Robert A.; Friedman, Jared; Jack, Anthony I.; Sattar, Abdus; Fresco, David M.; Rodriguez, Margaret; Moore, Shirley
• Is Part Of: Western journal of nursing research. Volume 41:Number 7(2019)
• Page Start: 990
• Page End: 1008
• Publication Date: 2019-07
• Subjects: HIV -- exercise -- fMRI -- behavioral interventions; Nursing -- Research -- Periodicals; Nursing -- Periodicals; Nursing -- Research -- West (U.S.) -- Periodicals; Nursing -- West (U.S.) -- Periodicals; Nursing -- Periodicals; Nursing Research -- Periodicals; Soins infirmiers -- Recherche -- Périodiques; Soins infirmiers -- Périodiques; Soins infirmiers -- Recherche -- États-Unis (Ouest) -- Périodiques; Soins infirmiers -- États-Unis (Ouest) -- Périodiques; Soins infirmiers; Recherche; États-Unis (Ouest); Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 610.730702
• DOI: 10.1177/0193945918823347
• Languages: English
• ISSNs: 0193-9459

Abstract

People living with HIV (PLHIV) are increasingly diagnosed with comorbidities which require increasing self-management. We examined the effect of a self-management intervention on neurocognitive behavioral processing. Twenty-nine PLHIV completed a two-group, 3-month randomized clinical trial testing a self-management intervention to improve physical activity and dietary intake. At baseline and 3 months later, everyone completed validated assessments of physical, diet, and neurocognitive processing (functional magnetic resonance imaging [fMRI]–derived network analyses). We used linear mixed effects modeling with a random intercept to examine the effect of the intervention. The intervention improved healthy eating ( p = .08) but did not improve other self-management behaviors. There was a significant effect of the intervention on several aspects of neurocognitive processing including in the task positive network (TPN) differentiation ( p = .047) and an increase in the default mode network (DMN) differentiation ( p = .10). Self-management interventions may influence neurocognitive processing in PLHIV, but those changes were not associated with positive changes in self-management behavior.