Atypical Perinuclear Anti-Neutrophil Cytoplasmic Antibodies in Ocular Inflammatory Diseases. (18th August 2019)

• Record Type: Journal Article
• Authors: Ebrahimiadib, Nazanin; Ma, Lina; Modjtahedi, Bobeck S.; Davoudi, Samaneh; Rahmani, Safa; Syeda, Sarah; Stephenson, Andrew; Foster, Charles Stephen
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 6(2019)
• Page Start: 937
• Page End: 941
• Publication Date: 2019-08-18
• Subjects: Anti-neutrophil cytoplasmic antibody -- atypical ANCA -- ocular inflammatory diseases -- scleritis -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1502787
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To characterize the clinical features of patients with ocular inflammatory diseases (OID) who tested positive for atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA). Methods : Retrospective case series of patients with OID seen at the Massachusetts Eye Research and Surgery Institute (MERSI) from April 2014 to April 2016. Results : 813 patients were tested for ANCA with 34 patients (4%) being positive for atypical P-ANCA. Among those with positive atypical P-ANCA, the most frequent diagnoses were anterior uveitis in 62% ( n = 21) followed by scleritis in 20% ( n = 7). Only one patient had an episode of recurrent disease flare-up. All but one patient, who had concomitant C-ANCA seropositivity and granulomatosis with polyangiitis, had a favorable disease course with controlled inflammation using topical and/or systemic immunomodulatory therapy. Conclusion : In contrast to typical C-ANCA and P-ANCA, atypical P-ANCA seropositivity was not associated with severe vasculitis or poor prognosis in patients with the OID.