Clinical Features of Scleritis Across the Asia-Pacific Region. (18th August 2019)

• Record Type: Journal Article
• Authors: Lane, Joshua; Nyugen, Ethan; Morrison, Julie; Lim, Lyndell; Stawell, Richard; Hodgson, Lauren; Bin Ismail, Muhammad Amir; Ling, Ho Su; Teoh, Stephen; Agrawal, Rupesh; Mahendradas, Padmamalini; Hari, Parvathi; Gowda, Poornachandra B.; Kawali, Ankush; McCluskey, Peter J.
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 6(2019)
• Page Start: 920
• Page End: 926
• Publication Date: 2019-08-18
• Subjects: Asia-Pacific -- autoimmune scleritis -- diffuse anterior scleritis -- infective scleritis -- necrotizing anterior scleritis -- nodular anterior scleritis -- posterior scleritis -- scleritis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1484496
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To examine the spectrum of scleritis in four tertiary institutions across the Asia-Pacific. Methods : Clinical records from 354 patients were reviewed from centers in Australia, Singapore, and India, excluding those with insufficient data ( n = 24). Results : Indian patients presented younger (41.5 ± 13.4 years) than Australians (50.8 ± 17.5) and Singaporeans (48.6 ± 15.9), with fewer women (49% vs 62%/57%). Diffuse disease was universally most common. Autoimmune and infectious disease proportions were similar in Australia (31%/10.3%) and Singapore (27.5%/8.3%) but reversed in India (8.3%/30%). Necrotizing scleritis was most frequently associated with infection (27.3%). Presumed ocular tuberculosis accounted for 75% of infectious cases in India. Posterior scleritis had the highest complication rate (82.4%) and immunosuppressants used per patient (0.98 ± 0.31 95% CI). Conclusions : Clinical presentations of scleritis vary across the Asia-Pacific, particularly in endemic regions for tuberculosis such as India, where it affects younger men with a predominance of nodular and infectious disease.