Histopathological analysis of papillary thyroid carcinoma detected during ultrasound screening examinations in Fukushima. Issue 2 (20th January 2019)

• Record Type: Journal Article
• Authors: Suzuki, Shinichi; Bogdanova, Tetiana I.; Saenko, Vladimir A.; Hashimoto, Yuko; Ito, Masahiro; Iwadate, Manabu; Rogounovitch, Tatiana I.; Tronko, Mykola D.; Yamashita, Shunichi
• Is Part Of: Cancer science. Volume 110:Issue 2(2019)
• Page Start: 817
• Page End: 827
• Publication Date: 2019-01-20
• Subjects: comparative study -- Fukushima nuclear accident -- mass screening -- papillary thyroid carcinoma -- surgical pathology; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.13912
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract : Thyroid ultrasound screening of young residents in Fukushima Prefecture, Japan, showed a high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after the nuclear accident of March 2011 in all available cases and in different age subgroups. Histological specimens of 115 PTCs from patients aged 18 years or younger at the time of the Fukushima Dai‐ichi Nuclear Power Plant accident, who underwent surgical resection at Fukushima Medical University during 2012‐2016, were reviewed. Patients were divided into those treated during the first 4 years after the accident (n = 78, shorter‐onset) or later (n = 37, longer‐onset). The whole group and 3 age subgroups: children (aged less than 15 years), adolescents (aged from 15 to less than 19 years), and young adults (aged from 19 years) at surgery were analyzed. No statistically significant time‐related changes in tumor structure or invasiveness were found in the whole group or in age‐matched subgroups. Statistically significant age‐related downtrend was observed for intrathyroid spread in the whole group of patients. The absence of temporal changes in tumor morphological characteristics and tumor invasiveness strongly suggests common etiology of the shorter‐ and longer‐onset Fukushima PTCs, which are unlikely related to the effect of exposure to very low doses of radiation. Abstract : Papillary thyroid carcinoma detected during ultrasound screenings of young residents in Fukushima Prefecture does not display significant changes of morphological structure or tumor invasiveness in time after the nuclear accident. The absence of temporal changes in qualitative tumor characteristics strongly suggests common etiology of the earlier‐ and longer‐onset cancers, which is unlikely related to the effect of exposure to very low doses of radiation.