The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering. (August 2018)

• Record Type: Journal Article
• Authors: Mathews, Juanita; Levin, Michael
• Is Part Of: Current opinion in biotechnology. Volume 52(2018)
• Page Start: 134
• Page End: 144
• Publication Date: 2018-08
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2018.03.008
• Languages: English
• ISSNs: 0958-1669

Abstract

Graphical abstract: Abstract : Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational control over anatomical structure and function. Recent successes in manipulating cellular and molecular hardware have not been matched by progress in understanding the patterning software implemented during embryogenesis and regeneration. A fundamental capability gap is driving desired changes in growth and form to address birth defects and traumatic injury. Here we review new tools, results, and conceptual advances in an exciting emerging field: endogenous non-neural bioelectric signaling, which enables cellular collectives to make global decisions and implement large-scale pattern homeostasis. Spatially distributed electric circuits regulate gene expression, organ morphogenesis, and body-wide axial patterning. Developmental bioelectricity facilitates the interface to organ-level modular control points that direct patterning in vivo . Cracking the bioelectric code will enable transformative progress in bioengineering and regenerative medicine.