Global DNA hypomethylation coupled to cellular transformation and metastatic ability. Issue 24 (19th November 2015)

• Record Type: Journal Article
• Authors: Funaki, Soichiro; Nakamura, Toshinobu; Nakatani, Tsunetoshi; Umehara, Hiroki; Nakashima, Hiroyuki; Okumura, Meinoshin; Oboki, Keisuke; Matsumoto, Kenji; Saito, Hirohisa; Nakano, Toru
• Is Part Of: FEBS letters. Volume 589:Issue 24(2015) Part B
• Page Start: 4053
• Page End: 4060
• Publication Date: 2015-11-19
• Subjects: DNA hypomethylation -- Transformation -- Metastasis -- Stella; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2015.11.020
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Global DNA hypomethylation and DNA hypermethylation of promoter regions are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumors is a consequence or a cause of cancer. Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells. Furthermore, overexpression of Stella enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis‐related genes. These results provide new insights into the function of global DNA hypomethylation in carcinogenesis. Abstract : Global DNA hypomethylation induced transformation of NIH3T3 cells. Global DNA hypomethylation enhanced metastatic ability of B16 melanoma cells. Stella will provide new insight into the role of DNA hypomethylation in cellular transformation and metastatic ability.