Effects of a mindfulness‐based weight loss intervention in adults with obesity: A randomized clinical trial. Issue 4 (9th March 2016)

• Record Type: Journal Article
• Authors: Daubenmier, Jennifer; Moran, Patricia J.; Kristeller, Jean; Acree, Michael; Bacchetti, Peter; Kemeny, Margaret E.; Dallman, Mary; Lustig, Robert H.; Grunfeld, Carl; Nixon, Douglas F.; Milush, Jeffrey M.; Goldman, Veronica; Laraia, Barbara; Laugero, Kevin D.; Woodhouse, Leslie; Epel, Elissa S.; Hecht, Frederick M.
• Is Part Of: Obesity. Volume 24:Issue 4(2016)
• Page Start: 794
• Page End: 804
• Publication Date: 2016-03-09
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21396
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: To determine whether adding mindfulness‐based eating and stress management practices to a diet‐exercise program improves weight loss and metabolic syndrome components. Methods: In this study 194 adults with obesity were randomized to a 5.5‐month program with or without mindfulness training and identical diet‐exercise guidelines. Intention‐to‐treat analyses with multiple imputation were used for missing data. The primary outcome was 18‐month weight change. Results: Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, −1.9 kg (95% CI: −4.5, 0.8; P = 0.17), and 18 months, −1.7 kg (95% CI: −4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, −3.1 mg/dl (95% CI: −6.3, 0.1; P = 0.06), and 18 months, −4.1 mg/dl (95% CI: −7.3, −0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, −0.57 (95% CI: −0.95, −0.18; P = 0.004), and 18 months, −0.36 (95% CI: −0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C‐reactive protein. Conclusions: Mindfulness enhancements to a diet‐exercise program did not show substantial weight loss benefit but may promote long‐term improvement in some aspects of metabolic health in obesity that requires further study.