The lncRNA MALAT1 protects the endothelium against ox‐LDL‐induced dysfunction via upregulating the expression of the miR‐22‐3p target genes CXCR2 and AKT. Issue 20 (10th September 2015)

• Record Type: Journal Article
• Authors: Tang, Yong; Jin, Xian; Xiang, Yin; Chen, Yu; Shen, Cheng-xing; Zhang, Ya-chen; Li, Yi-gang
• Is Part Of: FEBS letters. Volume 589:Issue 20(2015) Part B
• Page Start: 3189
• Page End: 3196
• Publication Date: 2015-09-10
• Subjects: CXCR2 -- miRNA-22-3p -- MALAT1 -- Endothelial cells -- ox-LDL; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2015.08.046
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : CXCR2 plays a key role in protecting the integrity of the endothelium. Emerging evidence has demonstrated that the long ncRNAs (lncRNA) Human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) participates in the regulation of the pathophysiological processes. However, whether there is crosstalk between CXCR2 and MALAT1 remains unknown. In this study, we demonstrated that MALAT1 was upregulated in patients with unstable angina. MALAT1 silencing significantly downregulated the expression of the miR‐22‐3p target gene CXCR2 via reversing the effect of the miR‐22‐3p, resulting in the aggravation of Oxidized low‐density lipoprotein (ox‐LDL)‐induced endothelial injury; this process was associated with the AKT pathway. Thus, MALAT1 protects the endothelium from ox‐LDL‐induced endothelial dysfunction partly through competing with miR‐22‐3p for endogenous RNA. Abstract : Mutual regulation exists between MALAT1 and miR‐22‐3p. miR‐22‐3p aggravates endothelial dysfunction via targeting CXCR2. MALAT1 protects endothelial cells through the miR‐22‐3p/CXCR2 axis. The miR‐22‐3p/CXCR2 axis is associated with AKT pathway.