Impact of intensive lifestyle intervention on preference‐based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Issue 4 (8th March 2016)

• Record Type: Journal Article
• Authors: Zhang, Ping; Hire, Don; Espeland, Mark A.; Knowler, William C.; Thomas, Sheikilya; Tsai, Adam G.; Glick, Henry A.
• Is Part Of: Obesity. Volume 24:Issue 4(2016)
• Page Start: 856
• Page End: 864
• Publication Date: 2016-03-08
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21445
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: To assess the effect of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) on preference‐based health‐related quality of life (HRQOL) in persons with overweight or obesity and type 2 diabetes. Methods: Look AHEAD was a multisite, randomized trial of 5, 145 participants assigned to ILI or DSE. Four instruments were administered during the trial: Feeling Thermometer (FT), Health Utilities Index Mark 2 (HUI2), Health Utilities Index Mark 3 (HUI3), and Short Form 6D (SF‐6D). Linear mixed effect models were used to estimate the mean difference in preference scores by treatment group for 9 years. Results: The ILI had higher mean FT (0.019, 95% CI, 0.015‐0.024, P < 0.001) and SF‐6D (0.011, 95% CI, 0.006‐0.014, P < 0.001) scores than the DSE. No significant group differences were observed for the HUI2 (0.004, 95% CI, −0.003 to 0.010, P = 0.23) and HUI3 (0.004, −0.004 to 0.012, P = 0.36). In year 1, the ILI had higher mean preference scores for all instruments. Thereafter, the increases remained significant only for FT and SF‐6D, and the effects also become smaller. Conclusions: ILI aimed at reducing body weight among persons with overweight or obesity and type 2 diabetes improves preference‐based HRQOL in the short term, but its long‐term effect is unclear.