The Predictive Factors Associated With Comorbidities for Treatment Response in Outpatients With King Classification III Diabetes Foot Ulcers. (December 2018)

• Record Type: Journal Article
• Authors: Su, Chun-Lin; Chang, Chang-Cheng; Peng, Yun-Shing; Chen, Mei-Yen
• Is Part Of: Annals of plastic surgery. Volume 81:(2018)Supplement 1 6S
• Publication Date: 2018-12
• Subjects: diabetic foot ulcers -- comorbidity -- King classification -- outcomes -- outpatient; Surgery, Plastic -- Periodicals; 617.95205
• DOI: 10.1097/SAP.0000000000001500
• Languages: English
• ISSNs: 0148-7043

Abstract

Abstract : Objective: The aim of this study is to investigate the preexisting predictive factors associated with comorbidities for diabetic foot ulcer (DFU) in King classification III at an outpatient clinic. Method: This prospective study included 100 patients with DFU in King classification III treated at outpatient clinics in Chiayi Chang Gung Memorial Hospital from January 2011 to December 2011. The least follow-up time was 1 year. Medical documentations were in respect of patient's baseline characteristics, associated history, presence of comorbidities, follow-up time, and condition of wounds. Patients were divided into success group (healed or healing with wound reduction), stagnate group, and failure group (amputation or infection, need in-hospital medical service) in accordance with the treatment response of wounds. χ 2 Test, Fisher exact test, and 1-way analysis of variance were used for variables in 3-group comparison, whereas Student t test was applied in 2-group comparison. The predictive factors with P value less than 0.1 were further investigated using the model of univariate logistic regression. Results: With 3-group stratification according to treatment response—failure (n = 8), stagnate (n = 22), and success (n = 70)—the occurrence rate of retinopathy was higher in the treatment stagnate group (42.1%) than in the treatment failure (14.3%) and success groups (12.5%; P = 0.019); the rate of previous percutaneous transluminal angioplasty (PTA) history was higher in the treatment failure group (25%) than in the treatment stagnate (4.8%) and success groups (1.5%; P = 0.020). With 2-group stratification—failure (n = 8) versus nonfailure (n = 92), and success (n = 70) versus nonsuccess (n = 30)—PTA history was strongly associated with treatment failure (odds ratio [OR], 14.33; 95% confidence interval [CI], 1.71–120.32; P = 0.014), whereas retinopathy (OR, 0.21; 95% CI, 0.07–0.65; P = 0.006) was the major negative predictor for treatment success. Previous debridement met borderline significance to predict treatment nonsuccess (OR, 0.09; 95% CI, 0.01–1.01; P = 0.051). Sex, age, associated history, dyslipidemia, hypertension, coronary artery disease, cerebrovascular accident, chronic kidney disease, and end-stage renal disease and wound condition had no statistical significance. Conclusions: Previous PTA and retinopathy, which indicated preexisting severe vasculopathy, are univariate predictive factors for treatment failure and nonsuccess, respectively, in patients with King classification III DFU. With the subdivision of King classification III DFU, medical history taking and fundus examination are acceptable methods for risk screening at an outpatient clinic.