Problems of reproductive function in survivors of childhood‐ and adolescent and young adult‐onset cancer revealed in a part of a national survey of Japan. (20th November 2018)

• Record Type: Journal Article
• Authors: Furui, Tatsuro; Takai, Yasushi; Kimura, Fuminori; Kitajima, Michio; Nakatsuka, Mikiya; Morishige, Ken‐ichiro; Higuchi, Akiko; Shimizu, Chikako; Ozawa, Miwa; Ohara, Akira; Tatara, Ryohei; Nakamura, Terukazu; Horibe, Keizo; Suzuki, Nao
• Is Part Of: Reproductive medicine and biology. Volume 18:Number 1(2019)
• Page Start: 105
• Page End: 110
• Publication Date: 2018-11-20
• Subjects: adolescent -- cancer survivors -- fertility preservation -- reproduction -- young adults; Reproduction -- Periodicals; Reproductive health -- Periodicals; 612.6
• DOI: 10.1002/rmb2.12255
• Languages: English
• ISSNs: 1445-5781

Abstract

Abstract: Purpose: This study aimed to evaluate the current status of reproductive disorders as long‐term complications in adolescent and young adult (AYA) cancer patients by comparing survivors of childhood‐onset with those of AYA‐onset cancer in Japan. Methods: We conducted a national survey of AYA cancer survivors and healthy AYAs and analyzed the results from survivors who underwent chemotherapy and reported fertility problems as their current concern. Results: Among all of the childhood‐onset survivors, 27 (35.5%; nine males [28.1%] and 18 females [40.9%]) listed reproduction fertility problems as their current concern. Among all AYA‐onset survivors, 25 (69.5%; 1/4 males [25.0%] and 24/32 females [75.0%]) listed these problems as a current concern. In contrast, 96.3% (26/27) of all childhood‐onset cancer survivors and 68.0% (17/25) of all AYA‐onset cancer survivors who received chemotherapy listed these problems as a current concern. Conclusions: A considerable number of both childhood‐onset and AYA‐onset cancer survivors, and especially those who had undergone chemotherapy, reported reproductive dysfunction as a delayed complication. It is vitally important to establish a supportive care system both for the patients whose fertility was abolished after the completion of cancer treatment and prophylactically for patients before they begin treatment. Abstract : The is the first report to discuss the current status of oncofertility in Japanese AYA cancer patients and survivors and to clarify its importance, focusing especially on the timing of the onset of their disease.