Telomere Length in Workers Was Effected by Omethoate Exposure, GSTM1 Deletion, Interaction Between Smoking and GSTP1 Polymorphisms. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Wang, Wei; Zhang, Hui; Duan, Xiaoran; Feng, Xiaolei; Wang, Tuanwei; Wang, Pengpeng; Ding, Mingcui; Liu, Suxiang; Li, Lei; Liu, Junling; Tang, Lixia; Niu, Xinhua; Zhang, Yuhong; Li, Guoyu; Yao, Wu; Yang, Yongli
• Is Part Of: Journal of occupational and environmental medicine. Volume 61:Issue 1(2019)
• Publication Date: 2019-01
• Subjects: generalized linear model -- metabolizing enzyme gene -- omethoate -- polymorphism -- telomere; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000001503
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: The aim of this study was to explore the association between telomere length and metabolizing enzyme gene polymorphisms and environmental factors in omethoate-exposed workers. Methods: The gene–environment interactions were analyzed with generalized linear model method. Results: The relative telomere lengths in the individuals with GSTM1- deletion were longer than that in non-deletion genotype in the control group ( P = 0.011); the relative telomere lengths with GG+AG genotypes in GSTP1 rs1695 were longer than that of AA genotype in the exposure group ( P = 0.039). The interaction between the GG+AG genotypes in GSTP1 rs1695 and smoking exposure had significant effect on telomere length ( P < 0.05). Conclusions: The prolongation of relative telomere length in omethoate-exposed workers was associated with GSTM1- deletion, GG+AG genotypes, and interactions of GG+AG genotypes and smoking factor.