Prevalence and Natural History of Coronary Ostial Aneurysms in Marfan Patients. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Haroun, Reham R.; Chu, Linda C.; Fishman, Elliot K.
• Is Part Of: Journal of computer assisted tomography. Volume 43:Issue 1(2019)
• Publication Date: 2019-01
• Subjects: aortic root replacement -- coronary ostial aneurysm -- CT angiography -- Marfan syndrome; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000799
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: The aim of this study was to determine the prevalence and natural history of coronary ostial aneurysms in Marfan patients with aortic root replacement. Methods: Thirty-one Marfan patients (mean age, 33.7 ± 11.8 years) who underwent aortic root replacement and postoperative electrocardiogram-gated computed tomographic (CT) angiograms between January 2007 and December 2015 were retrospectively identified. A subset of 15 patients underwent follow-up CT angiograms. Computed tomographic angiograms were postprocessed on 3-dimensional software to measure maximal coronary ostial diameter. Coronary ostial aneurysm was defined as diameter of greater than 10 mm. Results: Right coronary ostial aneurysms were present in 45.2% (14/31) of patients, and left main coronary ostial aneurysms were present in 51.6% (16/31) of patients. Mean ostial diameter was 10.1 ± 1.9 mm for the right coronary artery and 10.0 ± 1.8 mm for the left coronary artery. In a subset of patients with follow-up CT angiograms, there was no significant change in coronary ostial diameter on follow-up examinations ( P > 0.05). Conclusions: Coronary ostial aneurysms were common in Marfan patients after aortic root replacement. These findings remain stable over time and may have little clinical consequence.