Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP). (15th January 2019)

• Record Type: Journal Article
• Authors: Vilella, Laura; Lacuey, Nuria; Hampson, Johnson P.; Rani, M.R. Sandhya; Sainju, Rup K.; Friedman, Daniel; Nei, Maromi; Strohl, Kingman; Scott, Catherine; Gehlbach, Brian K.; Zonjy, Bilal; Hupp, Norma J.; Zaremba, Anita; Shafiabadi, Nassim; Zhao, Xiuhe; Reick-Mitrisin, Victoria; Schuele, Stephan; Ogren, Jennifer; Harper, Ronald M.; Diehl, Beate; Bateman, Lisa; Devinsky, Orrin; Richerson, George B.; Ryvlin, Philippe; Lhatoo, Samden D.
• Is Part Of: Neurology. Volume 92:Number 3(2019)
• Publication Date: 2019-01-15
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000006785
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. Methods: This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed. Results: We studied 148 GCS in 87 patients. Nineteen patients had generalized epilepsy; 65 had focal epilepsy; 1 had both; and the epileptogenic zone was unknown in 2. Ictal central apnea (ICA) preceded GCS in 49 of 121 (40.4%) seizures in 23 patients, all with focal epilepsy. Postconvulsive central apnea (PCCA) occurred in 31 of 140 (22.1%) seizures in 22 patients, with generalized, focal, or unknown epileptogenic zones. In 2 patients, PCCA occurred concurrently with asystole (near-SUDEP), with an incidence rate of 10.2 per 1, 000 patient-years. One patient with PCCA died of probable SUDEP during follow-up, suggesting a SUDEP incidence rate 5.1 per 1, 000 patient-years. No cases of laryngospasm were detected. Rhythmic muscle artifact synchronous with breathing was present in 75 of 147 seizures and related to stertorous breathing (odds ratio 3.856, 95% confidence interval 1.395–10.663, p = 0.009). Conclusions: PCCA occurred in both focal and generalized epilepsies, suggesting a different pathophysiology from ICA, which occurred only in focal epilepsy. PCCA was seen in 2 near-SUDEP cases and 1 probable SUDEP case, suggesting that this phenomenon may serve as a clinical biomarker of SUDEP. Larger studies are needed to validate this observation. Rhythmic postictal muscle artifact is suggestive of post-GCS breathing effort rather than a specific biomarker of laryngospasm.