UNUSUAL SEROUS RETINAL DETACHMENT IN A PATIENT WITH WALDENSTROM MACROGLOBULINEMIA: A CASE REPORT. Issue Volume 13:Issues 1(2019) (2019)

• Record Type: Journal Article
• Authors: Lin, Albert B.; Sheyman, Alan T.; Jampol, Lee M.
• Is Part Of: Retinal cases & brief reports. Volume 13:Issues 1(2019)
• Publication Date: 2019
• Subjects: maculopathy -- serous macular detachment -- retinal detachment -- Waldenstrom macroglobulinemia; Retina -- Diseases -- Periodicals; Retina -- Periodicals; Retinal Diseases -- Periodicals; Retina -- Case Reports; Retinal Diseases -- Case Reports; 617.7
• DOI: 10.1097/ICB.0000000000000540
• Languages: English
• ISSNs: 1935-1089

Abstract

Abstract : Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six–year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture. Abstract : The authors present the case of a patient with Waldenstrom macroglobulinemia who developed dramatic retinal architecture abnormalities after a prolonged period of sustained elevated IgM levels.