Model-based Modified OGTT Insulin Sensitivity Test Design. Issue 27 (2018)

• Record Type: Journal Article
• Authors: Holder-Pearson, Lui; Bekisz, Sophie; Knopp, Jennifer; Docherty, Paul; Chase, J. Geoffrey; Desaive, Thomas
• Is Part Of: IFAC-PapersOnLine. Volume 51:Issue 27(2018)
• Page Start: 86
• Page End: 91
• Publication Date: 2018
• Subjects: chronic diabetes care -- physiological model -- insulin -- insulin sensitivity -- OGTT; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2018.11.662
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: Type 2 diabetes mellitus requires early, accurate, and efficient monitoring for best treatment. Current common diagnosis tools either test late-appearing symptoms, are low resolution, or are expensive in cost and time. A system of physiological models for the oral ingestion of glucose, subcutaneous injection of insulin, and glycaemic control, are used to generate a quantitative test for insulin sensitivity. The proposed test uses 35g of oral glucose, 2.0 units of rapid-acting insulin, and both intra-venous and finger-prick blood samples for insulin, C-peptides, and blood glucose levels frequently over a 2-hour period. The test is developed in silico to enable early and repetitive monitoring of the pathogenesis of type 2 diabetes. In conjunction with emerging technologies in insulin sensing and needle-free delivery and monitoring devices, there is a pathway with this test to provide more effective, efficient early diagnosis of diabetes risk.