Efficient Hyperpolarization of U‐13C‐Glucose Using Narrow‐Line UV‐Generated Labile Free Radicals. (20th December 2018)

• Record Type: Journal Article
• Authors: Capozzi, Andrea; Patel, Saket; Gunnarsson, Christine Pepke; Marco‐Rius, Irene; Comment, Arnaud; Karlsson, Magnus; Lerche, Mathilde H.; Ouari, Olivier; Ardenkjær‐Larsen, Jan Henrik
• Is Part Of: Angewandte Chemie. Volume 131:Number 5(2019)
• Page Start: 1348
• Page End: 1353
• Publication Date: 2018-12-20
• Subjects: Glucose -- Hyperpolarisierung -- NMR-Spektroskopie -- Radikale; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201810522
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Free radicals generated by UV‐light irradiation of a frozen solution containing a fraction of pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) potential, providing up to 30 % [1‐ 13 C]PA liquid‐state polarization. Moreover, their labile nature has proven to pave a way to nuclear polarization storage and transport. Herein, differently from the case of PA, the issue of providing dDNP UV‐radical precursors (trimethylpyruvic acid and its methyl‐deuterated form) not involved in any metabolic pathway was investigated. The 13 C dDNP performance was evaluated for hyperpolarization of [U‐ 13 C6, 1, 2, 3, 4, 5, 6, 6‐d7 ]‐d ‐glucose. The generated UV‐radicals proved to be versatile and highly efficient polarizing agents, providing, after dissolution and transfer (10 s), a 13 C liquid‐state polarization of up to 32 %.