Fast discrimination of hydroxypropyl methyl cellulose using portable Raman spectrometer and multivariate methods. (21st December 2016)

• Record Type: Journal Article
• Authors: Song, Biao; Lu, Dan; Peng, Ming; Li, Xia; Zou, Ye; Huang, Meizhen; Lu, Feng
• Is Part Of: Laser physics. Volume 27:Number 2(2017:Feb.)
• Publication Date: 2016-12-21
• Subjects: portable Raman spectrometer -- PCA–FDA -- HPMC -- multivariate analysis; Lasers -- Periodicals; 621.36605
• DOI: 10.1088/1555-6611/aa4ffc
• Languages: English
• ISSNs: 1054-660X

Abstract

Abstract: Raman spectroscopy is developed as a fast and non-destructive method for the discrimination and classification of hydroxypropyl methyl cellulose (HPMC) samples. 44 E series and 41 K series of HPMC samples are measured by a self-developed portable Raman spectrometer (Hx-Raman) which is excited by a 785 nm diode laser and the spectrum range is 200–2700 cm −1 with a resolution (FWHM) of 6 cm −1 . Multivariate analysis is applied for discrimination of E series from K series. By methods of principal components analysis (PCA) and Fisher discriminant analysis (FDA), a discrimination result with sensitivity of 90.91% and specificity of 95.12% is achieved. The corresponding receiver operating characteristic (ROC) is 0.99, indicting the accuracy of the predictive model. This result demonstrates the prospect of portable Raman spectrometer for rapid, non-destructive classification and discrimination of E series and K series samples of HPMC.