From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis. Issue 68 (8th November 2018)

• Record Type: Journal Article
• Authors: Svezhentseva, Ekaterina V.; Vorotnikov, Yuri A.; Solovieva, Anastasiya O.; Pozmogova, Tatiana N.; Eltsov, Ilia V.; Ivanov, Anton A.; Evtushok, Darya V.; Miroshnichenko, Svetlana M.; Yanshole, Vadim V.; Eling, Charlotte J.; Adawi, Ali M.; Bouillard, Jean‐Sebastien G.; Kuratieva, Natalia V.; Fufaeva, Maria S.; Shestopalova, Lidiya V.; Mironov, Yuri V.; Efremova, Olga A.; Shestopalov, Michael A.
• Is Part Of: Chemistry. Volume 24:Issue 68(2018)
• Page Start: 17915
• Page End: 17920
• Publication Date: 2018-11-08
• Subjects: cluster compounds -- cytotoxicity -- hydrolysis -- molybdenum -- tungsten; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201804663
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water‐soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum. Abstract : Poor aqueous solubility and fast hydrolysis hinder the medical application of octahedral molybdenum clusters. Here, the first water‐soluble photoluminescent tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 is reported and its higher solubility towards hydrolysis in comparison with its molybdenum analogue is demonstrated. Biological studies suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis due to generation of nanoparticles.