High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019). Issue 2 (22nd January 2019)

• Record Type: Journal Article
• Authors: Cheng, Zhe A.; Alba‐Perez, Andres; Gonzalez‐Garcia, Cristina; Donnelly, Hannah; Llopis‐Hernandez, Virginia; Jayawarna, Vineetha; Childs, Peter; Shields, David W.; Cantini, Marco; Ruiz‐Cantu, Laura; Reid, Andrew; Windmill, James F. C.; Addison, Elena S.; Corr, Sandra; Marshall, William G.; Dalby, Matthew J.; Salmeron‐Sanchez, Manuel
• Is Part Of: Advanced science. Volume 6:Issue 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-22
• Subjects: biomaterials -- bone regeneration -- growth factor delivery -- stem cell differentiation; Science -- Periodicals; 505
• DOI: 10.1002/advs.201970009
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. Image credit: Aleixandre Rodrigo‐Navarro and Sara Trujillo‐Muñoz.