Thrombophilic risk factors are laterally associated with Apolipoprotein E gene polymorphisms in deep vein thrombosis patients: An Indian study. (June 2019)

• Record Type: Journal Article
• Authors: Rastogi, Pulkit; Kumar, Narender; Ahluwalia, Jasmina; Das, Reena; Varma, Neelam; Suri, Vikas; Senee, Harikishan
• Is Part Of: Phlebology. Volume 34:Number 5(2019)
• Page Start: 324
• Page End: 335
• Publication Date: 2019-06
• Subjects: Apolipoprotein E -- deep vein thrombosis -- genetic polymorphism -- thrombophilia; Veins -- Diseases -- Periodicals; 616.14
• DOI: 10.1177/0268355518802693
• Languages: English
• ISSNs: 0268-3555

Abstract

Introduction: Deep vein thrombosis is a multifactorial disease with many acquired and genetic risk factors. Polymorphism in the APOE gene is an upcoming potential pathogenic factor whose role is unclear in deep vein thrombosis. Methods: An equal number of deep vein thrombosis cases and controls (N = 100, each) were investigated for APOE gene polymorphisms along with known acquired and hereditable thrombophilic risk factors. APOE genotyping was done by polymerase chain reaction. Results: The ε3/ε4 and ε2/ε3 APOE genotypes were commoner in deep vein thrombosis cases than controls but not statistically significant ( ε3/ε4 → 18% versus 11%, OR = 1.776, CI = 0.792–3.984, p = 0.16; ε2/ε3 →10% versus 9%, OR = 1.123, CI = 0.436–2.895, p = 0.809). However, the following risk factors were found to be laterally associated with APOE genotypes in cases of deep vein thrombosis: pregnancy with ε2/ε3 genotype positivity (N = 29; p = 0.019), recurrent pregnancy loss with ε3/ε3 genotype (N = 29; p = 0.016), normal antithrombin levels with ε3/ε3 genotype (N = 62; p = 0.03) and non-O blood group with ε3/ε4 genotype (N = 100; p = 0.023). Conclusion: APOE genotypes have shown only a modest association with deep vein thrombosis and were not statistically significant. A lateral association of these genotypes with thrombophilic risk factors was observed which may be investigated further for the possible pathogenetic mechanisms and their therapeutic implications.