Risk of second primary cancers in women diagnosed with endometrial cancer in German and Swedish cancer registries. Issue 11 (29th August 2017)

• Record Type: Journal Article
• Authors: Chen, Tianhui; Brenner, Hermann; Fallah, Mahdi; Jansen, Lina; Castro, Felipe A.; Geiss, Karla; Holleczek, Bernd; Katalinic, Alexander; Luttmann, Sabine; Sundquist, Kristina; Ressing, Meike; Xu, Leiting; Hemminki, Kari
• Is Part Of: International journal of cancer. Volume 141:Issue 11(2017:Dec. 01)
• Page Start: 2270
• Page End: 2280
• Publication Date: 2017-08-29
• Subjects: second primary cancer -- endometrial cancer -- cancer registry -- etiology; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.30930
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997–2011 and in Sweden nationwide during 1997–2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets. Among 46, 929 endometrial cancer survivors in Germany and 18, 646 in Sweden, overall 2, 897 and 1, 706 SPCs were recorded, respectively. Significantly elevated SIRs were observed in Germany for ovarian (SIR = 1.3; 95%CI:1.1–1.5) and kidney cancers [1.6 (1.3–1.8)], while in Sweden the SIRs were 5.4 (4.6–6.3) and1.4 (1.0–1.9), respectively. Elevated risk for second ovarian endometrioid carcinoma was pronounced after early (<55 years) onset endometrial cancer in Germany [9.0 (4.8–15)] and Sweden [7.7 (5.1–11)]. In Germany elevated risks were found for second ovarian endometrioid carcinoma after endometrioid histology of first endometrial cancer [6.3 (4.0–9.4)] and for second kidney cancer after clear cell histology of endometrial cancer [4.9 (1.6–11)]. We found exceptionally elevated risk of second ovarian endometrioid carcinoma after endometrial cancer of the same histology or of early onset. Risk for second kidney cancer was also increased, particularly after endometrial cancer of clear cell histology. Cancer prevention strategies should focus on these cancers after endometrial cancer diagnosis. Abstract : What's new? Women who undergo treatment for endometrial cancer generally have a favorable prognosis. For some patients, however, improved survival leaves them vulnerable to the development of second primary cancers (SPCs). This study, based on analyses of cancer registry data for patients in Sweden and Germany, provides a comprehensive overview of the risk of specific SPCs in women diagnosed with endometrial cancer. In both patient populations, risk of SPCs of the ovaries or kidneys was elevated. Risk of second ovarian endometrioid carcinoma was especially high, however, potentially complicating outcomes for women who choose ovarian preservation during endometrial cancer surgery.