Laser welding of pre-functionalized glass substrates: a fabrication and chemical stability study. (1st December 2017)

• Record Type: Journal Article
• Authors: Carvalho, R R; Reuvekamp, S; Zuilhof, H; Blom, M T; Vrouwe, E X
• Is Part Of: Journal of micromechanics and microengineering. Volume 28:Number 1(2018:Jan.)
• Publication Date: 2017-12-01
• Subjects: laser welding -- glass -- microfluidics -- low temperature bonding; Microelectromechanical systems -- Periodicals; Micromechanics -- Periodicals; 621.38105
• DOI: 10.1088/1361-6439/aa9962
• Languages: English
• ISSNs: 0960-1317

Abstract

Abstract: Low-temperature bonding of glass substrates is of great interest in the field of microfluidic-based biosensing, and we study how laser welding could be used for this. This technology allows for the modification of glass channels with temperature-sensitive materials prior to bonding. We study the effects of the welding process by investigation of the thermal degradation of a biotin monolayer and whether it retains the ability to conjugate with fluorescently-labelled streptavidin.