Cyclopentyl Methyl Ether: An Elective Ecofriendly Ethereal Solvent in Classical and Modern Organic Chemistry. Issue 1 (20th November 2018)

• Record Type: Journal Article
• Authors: Azzena, Ugo; Carraro, Massimo; Pisano, Luisa; Monticelli, Serena; Bartolotta, Roberta; Pace, Vittorio
• Is Part Of: ChemSusChem. Volume 12:Issue 1(2019)
• Page Start: 40
• Page End: 70
• Publication Date: 2018-11-20
• Subjects: ethers -- green chemistry -- organometallic chemistry -- solvent effects -- synthetic methods; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201801768
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract: Solvents represent one of the major contributions to the environmental impact of fine‐chemical synthesis. As a result, the use of environmentally friendly solvents in widely employed reactions is a challenge of vast real interest in contemporary organic chemistry. Within this Review, a great variety of examples showing how cyclopentyl methyl ether has been established as particularly useful for this purpose are reported. Indeed, its low toxicity, high boiling point, low melting point, hydrophobicity, chemical stability towards a wide range of conditions, exceptional stability towards the abstraction of hydrogen atoms, relatively low latent heat of vaporization, and the ease with which it can be recovered and recycled enable its successful employment as a solvent in a wide range of synthetic applications, including organometallic chemistry, catalysis, biphasic reactions, oxidations, and radical reactions. Abstract : Ether way, it's good : Solvents contribute significantly to the environmental impact of fine‐chemical synthesis, and thus, the use of environmentally friendly solvents in widely employed reactions is of real interest in contemporary organic chemistry. Within this Review, a variety of examples showing how cyclopentyl methyl ether has been established as particularly useful for this purpose are reported.