Influences of Hunger, Satiety and Oral Glucose on Functional Brain Connectivity: A Multimethod Resting-State fMRI Study. (1st July 2018)

• Record Type: Journal Article
• Authors: Al-Zubaidi, Arkan; Heldmann, Marcus; Mertins, Alfred; Jauch-Chara, Kamila; Münte, Thomas F.
• Is Part Of: Neuroscience. Volume 382(2018)
• Page Start: 80
• Page End: 92
• Publication Date: 2018-07-01
• Subjects: ACC anterior cingulate cortex -- AINS anterior insula -- APCUNS anterior precuneus -- BMI body mass index -- BOLD blood oxygen-level-dependent -- CSF cerebrospinal fluid -- DARTEL diffeomorphic anatomical registration through exponentiated Liealgebra -- DC degree of centrality -- DMN default mode network -- DPARSFA data-processing assistant for resting-state fMRI advanced edition -- fALFF fractional amplitude of low-frequency fluctuations -- FC functional connectivity -- fMRI functional magnetic resonance imaging -- FSL FMRIB Software Library -- HS hippocampal structures -- ICA-AROMA independent component analysis (ICA)-based strategy for automatic removal of motion artifacts -- IFGorb orbital inferior frontal gyrus -- IPG inferior parietal gyrus -- K number of voxel per cluster -- KCC Kendall's coefficient concordance -- M mean -- MFG middle frontal gyrus -- MNI Montreal Neurological Institute -- PCC posterior cingulate cortex -- PET positron emission tomography -- PHG parahippocampal gyrus -- PoCG postcentral gyrus -- PreCG precentral gyrus -- ReHo regional homogeneity -- rm-ANOVA repeated measures analysis of variance -- rs-fMRI resting-state functional magnetic resonance imaging -- SD standard deviation -- SFG superior frontal gyrus -- SMA supplementary motor area -- SPM statistical parametric mapping -- TE echo time -- TR repetition time -- VAN ventral attention network; resting-state fMRI -- hunger -- satiety -- glucose administration -- functional connectivity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2018.04.029
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Multimethod rs-fMRI analysis reveals common hubs. Experiment identifies areas relevant for ingestive behavior. Experiment identifies interaction of metabolic state and glucose administration. Abstract: A major regulatory task of the organism is to keep brain functions relatively constant in spite of metabolic changes (e.g., hunger vs. satiety) or availability of energy (e.g., glucose administration). Resting-state functional magnetic resonance imaging (rs-fMRI) can reveal resulting changes in brain function but previous studies have focused mostly on the hypothalamus. Therefore, we took a whole-brain approach and examined 24 healthy normal-weight men once after 36 h of fasting and once in a satiated state (six meals over the course of 36 h). At the end of each treatment, rs-fMRI was recorded before and after the oral administration of 75 g of glucose. We calculated local connectivity (regional homogeneity [ReHo]), global connectivity (degree of centrality [DC]), and amplitude (fractional amplitude of low-frequency fluctuation [fALFF]) maps from the rs-fMRI data. We found that glucose administration reduced all measures selectively in the left supplementary motor area and increased ReHo and fALFF in the right middle and superior frontal gyri. For fALFF, we observed a significant interaction between metabolic states and glucose in the left thalamus. This interaction was driven by a fALFF increase after glucose treatment in the hunger relative to the satiety condition. Our results indicate that fALFF analysis is the most sensitive measure to detect effects of metabolic states on resting-state brain activity. Moreover, we show that multimethod rs-fMRI provides an unbiased approach to identify spontaneous brain activity associated with changes in homeostasis and caloric intake.