A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation. (July 2019)

• Record Type: Journal Article
• Authors: Squillaro, Anthony I; Zhou, Shengmei; Thomas, Stefanie M; Kim, Eugene S
• Is Part Of: Pediatric and developmental pathology. Volume 22:Number 4(2019)
• Page Start: 375
• Page End: 379
• Publication Date: 2019-07
• Subjects: precocious puberty -- sclerosing stromal tumor -- ovarian tumor -- breast bud development -- menarche -- thelarche; Pediatric pathology -- Periodicals; Children -- Diseases -- Periodicals; Diagnosis, Laboratory -- Periodicals; Abnormalities, Human -- Periodicals; Child development -- Periodicals; Pediatrics -- Periodicals; 616.07
• DOI: 10.1177/1093526618819605
• Languages: English
• ISSNs: 1093-5266

Abstract

Precocious puberty in an infant is an alarming and infrequent finding, making the differential diagnosis difficult for practitioners. Precocious puberty secondary to a sclerosing stromal tumor (SST) of the ovary is rare. We present a case of a child that began precocious puberty at 3 months of age including development of breast buds, pubic hair, growth spurt, and menarche 5 days prior to presenting to pediatric endocrinology at 10 months. She underwent right salpingo-oophorectomy which demonstrated a soft tissue mass occupying almost the entire ovary with a tan-pink fleshy cut surface. Histological examination confirmed a variant of SST. This case represents an extremely young onset of precocious puberty secondary to a variant of SST without hormonal elevation.