Γδ T cell responses: How many ligands will it take till we know?. (December 2018)

• Record Type: Journal Article
• Authors: Vermijlen, David; Gatti, Deborah; Kouzeli, Ariadni; Rus, Teja; Eberl, Matthias
• Is Part Of: Seminars in cell & developmental biology. Volume 84(2018)
• Page Start: 75
• Page End: 86
• Publication Date: 2018-12
• Subjects: APC antigen presenting cell -- BTN3 butyrophilin 3 (CD277) -- Btnl/BTNL butyrophilin-like -- CDR complementarity determining region -- CMV cytomegalovirus -- DC dendritic cell -- DETC dendritic epidermal T cell -- EPCR endothelial protein C receptor -- HMB-PP (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate -- IPP isopentenyl pyrophosphate -- MHC major histocompatibility complex -- MICA MHC complex class I chain-related protein A -- MR1 MHC related protein 1 -- TCR T cell receptor; Unconventional T cells -- T cell receptor -- Ligand recognition -- Innate immunity -- Adaptive immunity -- Stress immune surveillance -- Infection -- Cancer -- Immunotherapy; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2017.10.009
• Languages: English
• ISSNs: 1084-9521

Abstract

Graphical abstract: Highlights: Three decades of γδ T cell ligand discovery: Long and wasted years? Watchin' the river flow: Recent progress in understanding γδ TCR repertoires and specificities. Changing of the guards: Implications for therapy, vaccination and diagnosis. Abstract: γδ T cells constitute a sizeable and non-redundant fraction of the total T cell pool in all jawed vertebrates, but in contrast to conventional αβ T cells they are not restricted by classical MHC molecules. Progress in our understanding of the role of γδ T cells in the immune system has been hampered, and is being hampered, by the considerable lack of knowledge regarding the antigens γδ T cells respond to. The past few years have seen a wealth of data regarding the TCR repertoires of distinct γδ T cell populations and a growing list of confirmed and proposed molecules that are recognised by γδ T cells in different species. Yet, the physiological contexts underlying the often restricted TCR usage and the chemical diversity of γδ T cell ligands remain largely unclear, and only few structural studies have confirmed direct ligand recognition by the TCR. We here review the latest progress in the identification and validation of putative γδ T cell ligands and discuss the implications of such findings for γδ T cell responses in health and disease.