Relationship between the Dynamics of Orientation Tuning and Spatiotemporal Receptive Field Structures of Cat LGN Neurons. (1st May 2018)

• Record Type: Journal Article
• Authors: Li, Hongjian; Fang, Qi; Ge, Yijun; Li, Zhong; Meng, Jianjun; Zhu, Jianbing; Yu, Hongbo
• Is Part Of: Neuroscience. Volume 377(2018)
• Page Start: 26
• Page End: 39
• Publication Date: 2018-05-01
• Subjects: AE angle of elongation -- IM intramuscularly -- IV intravenously -- LGN lateral geniculate nucleus -- PSTHs peri-stimulus time histograms -- RFs receptive fields -- STRF spatiotemporal receptive field; cat -- lateral geniculate nucleus (LGN) -- spatiotemporal receptive field (STRF) -- orientation bias -- dynamics; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2018.02.024
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: STRF and dynamic orientation tuning was measured in a neuron of cat LGN. LGN neurons had elongated elliptical RFs from the very beginning. LGN neurons' orientation tuning matched the RFs' spatial structure at every moment. The appearance of orientation bias in LGN was earlier than the one in V1. Cortical ablation did not change the major findings. Abstract: Simple cells in the cat primary visual cortex usually have elongated receptive fields (RFs), and their orientation selectivity can be largely predicted by their RFs. As to the relay cells in cats' lateral geniculate nucleus (LGN), they also have weak but significant orientation bias (OB). It is thus of interest to investigate the fine spatiotemporal receptive field (STRF) properties in LGN, compare them with the dynamics of orientation tuning, and examine the dynamic relationship between STRF and orientation sensitivity in LGN. We mapped the STRFs of the LGN neurons in cats with white noise and characterized the dynamics of the orientation tuning by flashing gratings. We found that most of the LGN neurons showed elongated RFs and that the elongation axes were consistent with the preferred orientations. STRFs and the dynamics of orientation tuning were closely correlated temporally: the elongation of RFs and OB emerged, peaked and decayed at the same pace, with unchanged elongation axis of RF and preferred orientation but consistently changing aspect ratio of RF and OB strength across time. Importantly, the above consistency between RF and orientation tuning was not influenced by the ablation of the primary visual cortex. Furthermore, biased orientation tuning emerged 20–30 ms earlier than those in the primary visual cortex. These data demonstrated that similar to the primary visual cortex, the orientation sensitivity was closely reflected by the RF properties in LGN. However, the elongated RF and OB in LGN did not originate from the primary visual cortex feedback.