Synthesis, structural characterization and cytotoxicity studies of T-shaped silver(I) complexes derived from 1-benzyl-3H-benzimidazolium p-toluenesulfonates. (1st March 2018)

• Record Type: Journal Article
• Authors: Karlık, Özgül; Balcıoğlu, Sevgi; Karataş, Mert Olgun; Ateş, Burhan; Alıcı, Bülent; Özdemir, Namık
• Is Part Of: Polyhedron. Volume 142(2018)
• Page Start: 63
• Page End: 70
• Publication Date: 2018-03-01
• Subjects: Silver -- Benzimidazole -- Cytotoxicity -- Breast cancer -- Colorectal cancer; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2017.12.033
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Four novel aqua-bis(1-benzyl-2 H -benzimidazole)silver(I) p -toluenesulfonate complexes were synthesized and characterized. Anticancer properties of complexes were investigated against human cancer Caco-2 and MCF-7 cell lines. Among the complexes, 2b was found out as promising candidate for treatment of human colorectal cancer. Abstract: In the present study, we synthesized novel benzimidazole–silver(I) complexes (2a – d ) by the interaction of 1-benzyl-3 H -benzimidazolium p -toluenesulfonate derivatives (1a – d ) and Ag2 O in order to investigate their anticancer properties. All the salts and complexes were fully characterized by 1 H NMR, 13 C NMR, IR and LC–MS spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. Cytotoxic effects of compounds were investigated by MTT test against human colorectal (Caco-2), breast (MCF-7) cancer cell lines and non cancer mouse fibroblast (L-929) cell lines. All the complexes performed more cytotoxicity than cisplatin against Caco-2 cell lines while they were not active against MCF-7 in the treatment concentrations. Among the complexes, 2d which contains chlorine at 2-position of benzyl was found out as most active but not selective for non cancer L-929 cell lines. The complex2b which contains methyl instead of chlorine at2d showed approximately equal cytotoxicity as cisplatin against L-929 cell lines while this complex was twofold active than cisplatin against Caco-2 cell lines. These findings suggest that complex2b is a promising candidate for treatment of colorectal cancer.