2-(2-Nitrovinyl) furan exacerbates oxidative stress response of Escherichia coli to bacteriostatic and bactericidal antibiotics. (March 2018)

• Record Type: Journal Article
• Authors: Ajiboye, T.O.
• Is Part Of: Microbial pathogenesis. Volume 116(2018)
• Page Start: 130
• Page End: 134
• Publication Date: 2018-03
• Subjects: Reactive oxygen species -- 2-(2-Nitrovinyl) furan -- Fractional inhibitory concentration index -- Superoxide anion radical; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.01.010
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: The influence of 2-(2-nitrovinyl) furan on the activities of selected bacteriostatic and bactericidal antibiotics was investigated. Minimum inhibitory concentration and fractional inhibitory concentration index were determined to evaluate the interaction between 2-(2-nitrovinyl) furan and the antibiotics. 2-(2-nitrovinyl) furan exhibited additive interactions with chloramphenicol, erythromycin, lincomycin and gemifloxacin. However, synergistic interaction was observed with amoxicillin, ampicillin and ciprofloxacin. Superoxide anion content of Escherichia coli exposed to antibiotics with/without 2-(2-nitrovinyl) furan increased significantly ( p < .05). Furthermore, reduced glutathione decreased significantly with a corresponding increase in glutathione disulphide. In addition, malondialdehyde, a product of lipid peroxidation, increased significantly in E. coli exposed to antibiotics and 2-(2-nitrovinyl) furan. It can be deduced from this study that 2-(2-nitrovinyl) furan enhanced bacteriostatic and bactericidal antibiotics-mediated bacterial death possibly by potentiating reactive oxygen species generation and oxidative stress. Highlights: 2-(2-Nitrovinyl) furan increased antibiotic susceptibility. 2-(2-Nitrovinyl) furan enhanced superoxide generation. 2-(2-Nitrovinyl) furan enhanced antibiotic-mediated glutathione depletion. 2-(2-Nitrovinyl) furan enhanced antibiotic-mediated increase in malondialdehyde.