Resting-state Abnormalities in Heroin-dependent Individuals. (15th May 2018)

• Record Type: Journal Article
• Authors: Pandria, Niki; Kovatsi, Leda; Vivas, Ana B.; Bamidis, Panagiotis D.
• Is Part Of: Neuroscience. Volume 378(2018)
• Page Start: 113
• Page End: 145
• Publication Date: 2018-05-15
• Subjects: (λ⊥) radial diffusivity -- (λ∥) axial diffusivity -- ACC anterior cingulate cortex -- ADC apparent diffusion coefficient -- ALFF amplitude of low-frequency fluctuation -- BCI brain–computer interface -- BOLD blood oxygen level-dependent -- CC cingulate cortex -- CG Cingulate Gyrus -- CN cognitive normal -- CSF cerebrospinal fluid -- D degree -- DA brain dopamine system -- dACC dorsal aspect of ACC -- DCT discrete cosine transform -- DDT Delay-Discounting Task -- DLPFC dorsolateral prefrontal cortex -- DMN default-mode network -- DTI diffusion tensor imaging -- FA fractional anisotropy -- FFA fusiform area -- fMRI functional Magnetic Resonance -- FrSBe Frontal System Behavior Scale -- FTND Fagerstrom Test of Nicotine Dependence -- GM gray matter -- GTA Graph theory analysis -- HD heroin-dependent -- HG Heroin Group -- iAFC intrinsic amygdala functional network -- ICA independent component analysis -- IFG inferior frontal gyrus -- IGT Iowa Gambling Test -- ILF inferior longitudinal fasciculus -- IPL inferior parietal lobe -- IPL Inferior Parietal Lobule -- MCC middle cingulate gyrus -- MCP cerebellar peduncles -- MeFG medial frontal gyrus -- MPFC medial prefrontal cortex -- NAc nucleus accumbens -- OD opiate dependent -- OFC orbitofrontal cortex -- PA prolonged abstinent -- PCC/pC posterior cingulate cortex/precuneus -- PFC prefrontal cortex -- PG placebo group -- PHG parahippocampal gyrus -- phMRI pharmacological MRI -- PSA polysubstance users -- PSAP Point Subtraction Aggression Paradigm -- rACC, rostral aspect of ACC -- rCBF resting cerebral blood flow -- RD radial diffusivity -- Region of Interest – approach ROI-approach -- rsFC resting-state functional connectivity -- SC structural connectivity -- SLF superior longitudinal fasciculus -- SMA supramarginal motor area -- SMC supplementary motor cortex -- TIV total intracranial volume -- vACC ventral part of ACC -- vmPFC ventral medial prefrontal cortex -- VTA ventral tegmental area; heroin addiction -- resting-state -- functional and structural connectivity -- small-world properties -- behavioral traits of heroin-dependent individuals; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.11.018
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Existing literature on resting-state connectivity in heroin-dependent individuals. Functional, structural and topological alterations in heroin addicts. Heroin-induced behavioral modulations. Limitations of the existing knowledge and future perspectives. Abstract: Drug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific prefrontal, parietal, occipital, and temporal regions, as well as, some subcortical regions. The brain regions involved are usually linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control and seem to form circuits that interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively review and discuss existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapy a multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games.