Neural Correlates of Success and Failure Signals During Neurofeedback Learning. (15th May 2018)

• Record Type: Journal Article
• Authors: Radua, Joaquim; Stoica, Teodora; Scheinost, Dustin; Pittenger, Christopher; Hampson, Michelle
• Is Part Of: Neuroscience. Volume 378(2018)
• Page Start: 11
• Page End: 21
• Publication Date: 2018-05-15
• Subjects: BOLD blood-oxygen-level dependent -- ERN event-related negativity -- fMRI functional magnetic resonance imaging -- MePFC medial prefrontal cortex -- OFC orbitofrontal cortex -- Pc/PCC precuneus/posterior cingulate cortex -- rt-fMRI real-time functional magnetic resonance imaging; failure -- feedback -- functional magnetic resonance imaging (fMRI) -- learning -- neurofeedback -- success; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.04.003
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Signals of failure correlated early during learning with deactivation in the precuneus. Signals of success correlated later with deactivation in the anterior cingulate cortex. Intensity of the latter predicted the efficacy of the neurofeedback intervention. Abstract: Feedback-driven learning, observed across phylogeny and of clear adaptive value, is frequently operationalized in simple operant conditioning paradigms, but it can be much more complex, driven by abstract representations of success and failure. This study investigates the neural processes involved in processing success and failure during feedback learning, which are not well understood. Data analyzed were acquired during a multisession neurofeedback experiment in which ten participants were presented with, and instructed to modulate, the activity of their orbitofrontal cortex with the aim of decreasing their anxiety. We assessed the regional blood-oxygenation-level-dependent response to the individualized neurofeedback signals of success and failure across twelve functional runs acquired in two different magnetic resonance sessions in each of ten individuals. Neurofeedback signals of failure correlated early during learning with deactivation in the precuneus/posterior cingulate and neurofeedback signals of success correlated later during learning with deactivation in the medial prefrontal/anterior cingulate cortex. The intensity of the latter deactivations predicted the efficacy of the neurofeedback intervention in the reduction of anxiety. These findings indicate a role for regulation of the default mode network during feedback learning, and suggest a higher sensitivity to signals of failure during the early feedback learning and to signals of success subsequently.