Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study. Issue 3 (June 2018)

• Record Type: Journal Article
• Authors: Serra-Mir, M.; Pérez-Heras, A.; Viñas, C.; Casas, R.; Medina-Renom, A.; Baena, J.M.; García, M.; Oller, M.; Amat, J.; Duaso, I.; García, Y.; Iglesias, C.; Simón, C.; Quinzavos, L.; Parra, L.; Liroz, M.; Benavent, J.; Clos, J.; Pla, I.; Amorós, M.; Bonet, M.T.; Martín, M.T.; Sánchez, M.S.; Altirriba, J.; Manzano, E.; Altés, A.; Cofán, M.; Valls-Pedret, C.; Sala-Vila, A.; Doménech, M.; Bulló, M.; Babio, N.; Basora, J.; González, R.; Molina, C.; Márquez, F.; Martínez, P.; Ibarrola, N.; Sorlí, M.; García Roselló, J.; Castro, A.; Martin, F.; Tort, N.; Isach, A.; Guasch-Ferre, M.; Cabré, J.J.; Mestres, G.; Paris, F.; Llauradó, M.; Pedret, R.; Basells, J.; Vizcaino, J.; Segarra, R.; Frigola, J.; Costa-Vizcaino, J.; Salas-Huetos, A.; Boj, J.; Montañes, D.; Papandreou, Christopher; Fernández-Ballart, J.; Carrasco, P.; Ortega-Azorín, C.; Asensio, E.M.; Osma, R.; Barragán, R.; Francés, F.; Guillén, M.; González, J.I.; Sáiz, C.; Portolés, O.; Giménez, F.J.; Coltell, O.; Fernández-Carrión, R.; Guillem-Sáiz, P.; González-Monje, I.; Quiles, L.; Pascual, V.; Riera, C.; Pages, M.A.; Godoy, D.; Carratalá-Calvo, A.; Sánchez-Navarro, S.; Valero-Barceló, C.; Tello, S.; Vila, J.; de la Torre, R.; Muñoz-Aguayo, D.; Elosua, R.; Marrugat, J.; Schröder, H.; Molina, N.; Maestre, E.; Rovira, A.; Castañer, O.; Farré, M.; Toledo, E.; Ruiz-Canela, M.; Sanjulián, B.; Sánchez-Tainta, A.; Eguaras, S.; Martí, A.; Buil-Cosiales, P.; SerranoMartínez, M.; Diez-Espino, J.; García-Arellano, A.; Martínez-Lapiscina, E.H.; Goñi, E.; Vázquez, Z.; Berrade, N.; Extremera-Urabayen, V.; Arroyo-Azpa, C.; García-Pérez, L.; Villanueva-Telleria, J.; Cortés-Ugalde, F.; Sagredo-Arce, T.; Vigata-López, M.D.; Arceiz Campo, M.T.; Urtasun-Samper, A.; Gueto Rubio, M.V.; Churio-Beraza, B.; Arós, F.; Salaverria, I.; del Hierro, T.; Algorta, J.; Francisco, S.; Alonso-Gómez, A.; Sanz, E.; Rekondo, J.; Belló, M.C.; Loma-Osorio, A.; Gómez-Gracia, E.; Wärnberg, J.; Benítez Pont, R.; Bianchi Alba, M.; Gómez-Huelgas, R.; Martínez-González, J.; Velasco García, V.; de Diego Salas, J.; Baca Osorio, A.; Gil Zarzosa, J.; Sánchez Luque, J.J.; Vargas López, E.; Ruiz-Gutiérrez, V.; Sánchez Perona, J.; Montero Romero, E.; García-García, M.; Jurado-Ruiz, E.; Fiol, M.; Romaguera, D.; García-Valdueza, M.; Moñino, M.; Munuera, S.; Vivó, M.; Bestard, F.; Munar, J.A.; Coll, L.; Proenza, A.; Prieto, R.; Frontera, G.; Fiol, F.; Ginard, M.; Jover, A.; García, J.; Santos-Lozano, J.M.; Ortega-Calvo, M.; Mellado, L.; García-Corte, F.J.; Román, P.; Iglesias, P.; Corchado, Y.; Miró-Moriano, L.; Domínguez-Espinaco, C.; Lozano-Rodriguez, J.M.; Vaquero-Diaz, S.; López- Sabater, M.C.; Castellote-Bargalló, A.I.; Quifer-Rada, P.; Tresserra-Rimbau, A.; Álvarez-Pérez, J.; Díaz-Benítez, E.M.; Sánchez-Villegas, A.; Casañas-Quintana, L.T.; Pérez-Cabrera, J.; Ruano-Rodríguez, C.; Bautista-Castaño, I.; Sarmiento de la Fe, F.; García Pastor, J.A.; Díaz-González, B.V.; Castillo Anzalas, J.M.; Sosa-Also, R.E.; Medina-Ponce, J.; de la Cruz, E.; Fanlo-Maresma, M.; Galera, A.; Trias, F.; Sarasa, I.; Corbella, E.; Corbella, X.; Cabezas, C.; Vinyoles, E.; Rovira, M.A.; García, L.; Flores, G.; Verdú, J.M.; Baby, P.; Ramos, A.; Mengual, L.; Roura, P.; Yuste, M.C.; Guarner, A.; Santamaría, M.I.; Mata, M.; de Juan, C.; Brau, A.; Tur, J.A.; Portillo, M.P.; Sáez, G.; Arós, F.; Aldamiz-Echevarría, M.; Alonso-Gómez, A.M.; Berjón, J.; Forga, L.; Gállego, J.; García-Layana, A.; Larrauri, A.; Portu-Zapirain, J.; Timiraus-Fernández, J.; Becerra-Tomás, Nerea; Díaz-López, Andrés; Rosique-Esteban, Núria; Ros, Emilio; Buil-Cosiales, Pilar; Corella, Dolores; Estruch, Ramon; Fitó, Montserrat; Serra-Majem, Lluís; Arós, Fernando; Lamuela-Raventós, Rosa Maria; Fiol, Miquel; Santos-Lozano, José Manuel; Díez-Espino, Javier; Portoles, Olga; Salas-Salvadó, Jordi;
• Is Part Of: Clinical nutrition. Volume 37:Issue 3(2018)
• Page Start: 906
• Page End: 913
• Publication Date: 2018-06
• Subjects: Legumes -- Lentils -- Type 2 diabetes -- PREDIMED-study; IDF International Diabetes Federation -- CVD cardiovascular disease -- MedDiet Mediterranean diet -- PREDIMED PREvención con DIeta MEDiterránea -- FFQ Food Frequency Questionnaire -- ICC intraclass correlation coefficient -- HRs hazard ratios -- Cis Confidence intervals -- METs metabolic equivalent task; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2017.03.015
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P- trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P- trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P -trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered athttp://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.