Phase-specific Surround suppression in Mouse Primary Visual Cortex Correlates with Figure Detection Behavior Based on Phase Discontinuity. (21st May 2018)

• Record Type: Journal Article
• Authors: Li, Fengling; Jiang, Weiqian; Wang, Tian-Yi; Xie, Taorong; Yao, Haishan
• Is Part Of: Neuroscience. Volume 379(2018)
• Page Start: 359
• Page End: 374
• Publication Date: 2018-05-21
• Subjects: 2AFC two-alternative forced choice -- AAV adeno-associated virus -- ACSF artificial cerebrospinal fluid -- CSD current source density -- LFP local field potential -- LGN lateral geniculate nucleus -- PSSI phase-specific suppression index -- PV parvalbumin -- RF receptive field -- ROC receiver operating characteristic -- SC superior colliculus -- SF spatial frequency -- SI suppression index -- SOM somatostatin -- V1 primary visual cortex -- V2 secondary visual cortex; contextual modulation -- figure-ground -- optogenetics -- rodent -- visual behavior; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2018.03.039
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Behavioral performance of figure detection increases with the phase difference between figure and ground stimuli. V1 neural discrimination between stimuli with and without center-surround phase difference is higher at larger difference. Silencing V1 decreases the behavioral performance of figure detection based on phase discontinuity. Abstract: In the primary visual cortex (V1), neuronal responses to stimuli within the receptive field (RF) are modulated by stimuli in the RF surround. A common effect of surround modulation is surround suppression, which is dependent on the feature difference between stimuli within and surround the RF and is suggested to be involved in the perceptual phenomenon of figure-ground segregation. In this study, we examined the relationship between feature-specific surround suppression of V1 neurons and figure detection behavior based on figure-ground feature difference. We trained freely moving mice to perform a figure detection task using figure and ground gratings that differed in spatial phase. The performance of figure detection increased with the figure-ground phase difference, and was modulated by stimulus contrast. Electrophysiological recordings from V1 in head-fixed mice showed that the increase in phase difference between stimuli within and surround the RF caused a reduction in surround suppression, which was associated with an increase in V1 neural discrimination between stimuli with and without RF-surround phase difference. Consistent with the behavioral performance, the sensitivity of V1 neurons to RF-surround phase difference could be influenced by stimulus contrast. Furthermore, inhibiting V1 by optogenetically activating either parvalbumin (PV)- or somatostatin (SOM)-expressing inhibitory neurons both decreased the behavioral performance of figure detection. Thus, the phase-specific surround suppression in V1 represents a neural correlate of figure detection behavior based on figure-ground phase discontinuity.