Disposition of fragrance ingredient [14C]1-(1, 2, 3, 4, 5, 6, 7, 8-octahydro-2, 3, 8, 8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. (17th February 2014)

• Record Type: Journal Article
• Authors: Waidyanatha, Suramya; Ryan, Kristen
• Is Part Of: Xenobiotica. Volume 44:Number 8(2014:Aug.)
• Page Start: 749
• Page End: 756
• Publication Date: 2014-02-17
• Subjects: 1-(1, 2, 3, 4, 5, 6, 7, 8-Octahydro-2, 3, 8, 8-tetramethyl-2-naphthalenyl)ethanone -- biliary excretion -- dermal absorption -- enterohepatic recirculation -- fragrance ingredient -- oral absorption; Metabolism -- Periodicals; Drugs -- Physiological effect -- Periodicals; Food additives -- Periodicals; Chemicals -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; Metabolism -- Periodicals; 574.133
• DOI: 10.3109/00498254.2014.888489
• Languages: English
• ISSNs: 0049-8254

Abstract

Abstract: 1. Disposition of 1-(1, 2, 3, 4, 5, 6, 7, 8-octahydro-2, 3, 8, 8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [ 14 C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [ 14 C]β-OTNE. 3. Following dermal application to a covered site, absorption of [ 14 C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [ 14 C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [ 14 C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure.