Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases. (14th July 2019)

• Record Type: Journal Article
• Authors: Dort, Junio; Fabre, Paul; Molina, Thomas; Dumont, Nicolas A.
• Other Names: Lyu Fengjuan Guest Editor.
• Is Part Of: Stem cells international. Volume 2019(2019)
• Publication Date: 2019-07-14
• Subjects: Stem Cells -- Periodicals; Stem Cells -- Therapeutic use -- Periodicals; Stem Cells -- Transplantation -- Periodicals; 616.0277405
• DOI: 10.1155/2019/4761427
• Languages: English
• ISSNs: 1687-966X

Abstract

Abstract : Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged as a central actor coordinating the different cellular interactions and biological processes. Particularly, the transition of macrophages from their proinflammatory to their anti-inflammatory phenotype was shown to regulate inflammation, myogenesis, fibrosis, vascularization, and return to homeostasis. On the other hand, deregulation of macrophage accumulation or polarization in chronic degenerative muscle disorders was shown to impair muscle regeneration. Considering the key roles of macrophages in skeletal muscle, they represent an attractive target for new therapeutic approaches aiming at mitigating various muscle disorders. This review aims at summarizing the novel insights into macrophage heterogeneity, plasticity, and functions in skeletal muscle homeostasis, regeneration, and disease.