Neural correlates of visual attention in alcohol use disorder. (1st January 2019)

• Record Type: Journal Article
• Authors: Zehra, Amna; Lindgren, Elsa; Wiers, Corinde E.; Freeman, Clara; Miller, Gregg; Ramirez, Veronica; Shokri-Kojori, Ehsan; Wang, Gene-Jack; Talagala, Lori; Tomasi, Dardo; Volkow, Nora D.
• Is Part Of: Drug and alcohol dependence. Volume 194(2019)
• Page Start: 430
• Page End: 437
• Publication Date: 2019-01-01
• Subjects: Dorsal attention network -- Ventral attention network -- Cognition -- fMRI -- Brain imaging; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2018.10.032
• Languages: English
• ISSNs: 0376-8716

Abstract

Highlights: Alcohol use disorder (AUD) is associated with cognitive impairments. AUD participants and healthy controls (HC) completed a visual attention task (VAT). Groups did not differ in behavioral performance on the VAT during fMRI. AUD showed lower brain activation than HC in regions associated with attention. These results suggest differences in attentional networks in AUD compared to HC. Abstract: Numerous studies have documented cognitive impairments in multiple domains in patients with an alcohol use disorder (AUD), including perceptuomotor, executive, and visuospatial functions. Although the neural underpinnings of cognitive deficits in AUD have been studied extensively, the neural basis of attention deficits in AUD remains relatively unexplored. Here, we investigated neural responses to a visual attention task (VAT) in 19 recently abstinent patients with AUD and 23 healthy control participants (HC) using functional MRI (fMRI). AUD had a mean number of 62 ± 34SD drinks per week and 29 ± 13 years' history of alcohol use. Results show that there were no behavioral differences (accuracy or reaction time) between groups during the VAT. For both groups, the VAT activated brain areas associated with visual attention load (i.e., parietal and prefrontal cortices) and visual processing (i.e., occipital cortex), which is in line with previous reports on the same task in healthy volunteers. Despite similar behavioral performances, AUD participants showed decreased VAT activation in regions of the dorsal and ventral attention networks, including parietal and prefrontal cortices, and in the insula as compared to controls. These findings corroborate differences in attention networks in AUD compared to HC that might underlie attention deficits in AUD, whereas impairments in the insula could reflect a disruption of interoception processing as found in other addictions.