Prognostic Value of Combined Analysis of CTLA-4 and PLR in Esophageal Squamous Cell Carcinoma (ESCC) Patients. (14th August 2019)

• Record Type: Journal Article
• Authors: Zhang, Cui-Ying; Zhang, Juan; Ma, Yun-Fan; Zhe, Hong; Zhao, Ren; Wang, Yan-Yang
• Other Names: Tacke Frank Academic Editor.
• Is Part Of: Disease markers. Volume 2019(2019)
• Publication Date: 2019-08-14
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2019/1601072
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objective . The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients. Methods . 84 ESCC patients who received surgical treatment in our hospital were enrolled in the study. The correlation of each biomarker's level with ESCC patients' clinicopathological characteristics and overall survival (OS) was assessed. Results . The elevated expression rate of T-CTLA-4 (tumor cell CTLA-4) and I-CTLA-4 (interstitial lymphocyte CTLA-4) was 48.8% and 44.0%, respectively. The number of enrolled patients with a higher PLR level (≥119) was 48. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. However, patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS (p = 0.023 ) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was also confirmed in multivariate analyses (p = 0.027 ). Conclusion . These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients.